法国国家健康与医学研究院（INSERM）2023年招聘博士后职位（免疫学）

法国国家健康与医学研究院（法文为：Institut national de la santé et de la recherche médicale），简称“Inserm”，成立于1964年，是一所总部位于法国巴黎的国家级公共科学和技术研究机构，其前身是成立于1941年的法国国家卫生研究院，由法国卫生部和研究部共同管理。Inserm是法国唯一一个完全致力于人类健康的公共研究组织，参与从研究到治疗的全过程，其宗旨通过增进对生命和疾病的知识、创新治疗方法和公共卫生研究，促进全人类健康。

Postdoctoral Researcher In Immunology : Mechanisms Of Hepatitis E Virus Immunopathogenesis In Solid Organ Transplant Recipients

Universities and Institutes of France

France

November 01, 2023

Contact:N/A

Offerd Salary:Negotiation

Location:N/A

Working address:N/A

Contract Type:Other

Working Time:Full time

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Ref info:N/A

28 Aug 2023

Job Information

Organisation/Company

INSERM

Department

U1291

Research Field

Biological sciences » Biology

Medical sciences » Health sciences

Researcher Profile

Recognised Researcher (R2)

Country

France

Application Deadline

1 Nov 2023 - 23:00 (Europe/Paris)

Type of Contract

Temporary

Job Status

Full-time

Offer Starting Date

1 Jan 2024

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

Yes

Offer Description

Project Title

Postdoctoral Researcher in Immunology : Mechanisms of hepatitis E virus immunopathogenesis in solid organ transplant recipients

Research Project

Hepatitis E virus genotype 3 (HEV) establishes mostly asymptomatic, self- limiting infection in immunocompetent individuals. However, in immunocompromised patients with solid organ transplant the infection progresses frequently to a chronic course. To date, the mechanisms involved in viral persistence remain to be discovered.

The overall objective of the current project is to investigate, at the cellular and molecular levels, the function of immune cells, particularly T cells, at the acute stage of the infection in order to unveil their role in viral persistence/clearance. To this end, cryopreserved PBMC and plasma samples (collected at the early and late phases of the infection) from infected and uninfected transplanted patients will be used. T cell subsets will be studied with embedded levels of analysis (phenotype, function, metabolism, gene expression) by flow cytometry and single cell Cite-seq. Additional metabolomics and proteomics studies will also be conducted on plasma samples.

Main Activities

· To be responsible for the development of the research project: plan experiments, analyze and interpret experimental data, report regularly to the supervisor and team members on scientific activities and maintain accurate and up-to-date records of all findings.

· To maintain an up-to-date awareness of relevant publications in the area of research.

· To participate in publications and funding request writing.

· To train and supervise junior members of the team.

Associated Activities

· To participate in the team project (experiments and analyses).

Scientific Environment

The Toulouse Institute for Infectious and Inflammatory diseases (INFINITy) provides a stimulating environment to perform state-of-the-art research in immunology and infectious diseases, with integrated on-site technological facilities. Research teams at the Center host international trainees of various nationalities, ranging from undergraduate students to postdocs. External seminars and lab meetings are held in English.

The host team, headed by Dr. Jabrane-Ferrat is currently composed of 9 members working collaboratively. The candidate will be supervised by the Dr. H. El Costa (PI). The research project will be in close collaboration with the French Nation Reference Center for entero-transmissible hepatitis E (Pr. J. Izopet and Dr. F. Abravanel).

Requirements

Research Field

Biological sciences » Biology

Education Level

PhD or equivalent

Skills/Qualifications

· The applicant should have a strong expertise and proven research skills in T cells biology and immunology techniques such as multiparametric flow cytometry (FACS Symphony A5, Spectral Cytek Aurora) and metabolism analyses (Seahorse, Scenith).

· Proven practical experience in bioinformatics/Omics are mandatory.

· Experience using flow cytometry analysis software (OMIQ, FlowJo), statistical programs such as Prism and Microsoft office programs (Excel, PowerPoint, Word).

· Excellent communication skills, team spirit, capacity to work autonomously and deliver results on time.

Specific Requirements

PhD in immunology with 2 years of postdocoral experience.

Handling human samples in a 2/3 level containment laboratory.

Possible outside working hours.

Languages

ENGLISH

Level

Excellent

Languages

FRENCH

Level

Basic

Research Field

Biological sciences » Biology

Years of Research Experience

1 - 4

Additional InformationWork Location(s)

Number of offers available

1

Company/Institute

Toulouse Institute for Infectious and Inflammatory Diseases

Country

France

City

Toulouse

Postal Code

31024

Street

CHU Purpan

Geofield

Where to apply

E-mail

hicham.el-costa@inserm.fr

Contact

City

Toulouse

Website

https: // www. infinity.inserm.fr/en/

Street

1 place, docteur Baylac

Postal Code

31024

E-Mail

hicham.el-costa@inserm.fr

Phone

0562748370

STATUS: EXPIRED