法国巴斯德研究院2024年招聘博士后职位（肠道病毒重组研究）

法国巴斯德研究院属私人基金会性质，于1888年11月14日，经由国际募款正式成立。其目的在于帮助路易斯·巴斯德进行扩大防狂犬疫苗的接种、传染病的研究与相关知识的宣导。

法国巴斯德研究院主要工作为传染病防治的研究教学以及公共卫生服务，尤其关注狂犬病、鼠疫、白喉、破伤风、斑疹伤寒、黄热病、结核病、脊髓灰质炎、B型肝炎及艾滋病的研究。研究院在类毒素、BCG、磺胺、抗组胺上的发现享有盛誉，研究范围触及分子生物学与遗传工程生物学的领域。

Postdoc position to study recombination among enteroviruses

Institut Pasteur

France

March 24, 2024

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Working Time:Negotigation

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A postdoctoral position is available at Institut Pasteur (Virus Sensing & Signaling Unit) to investigate the role played by recombination in the evolution of enteroviruses. This project takes place in the framework of the deployment of the new oral polio vaccine by the Global Polio Eradication Initiative.

The position is part of a large consortium made of the polio lab hosted by the Institut Pasteur and members of the Pasteur Network in Algeria, Guinea, Cameroon, Central African Republic and Madagascar. The main goal of the project is to get new insights about the circulation of non-polio enteroviruses that recombine with the vaccine polio strains, so causing reversion of the attenuated phenotype. This part of the project will involve the analysis of sequencing data (Illumina and Minion) and phylogenetic analysis. Besides, in vitro experiments using reverse genetics will be carried out to study how recombination events shape the evolution of the enteroviruses. This project will include work with infectious material.

Qualifications

Applicants must hold (or be about to obtain) a PhD in a relevant field such as virology. Prior wet-lab experience is required. Experience in molecular epidemiology and biosafety level-3 proficiency would be a significant advantage. High motivation, impeccable work ethics, excellent communication skills and ability to work collaboratively are essential.

The position is available immediately and will remain open until filled. The expected start date (negotiable) is before mid-2024. The position is for 24 months. Salary will be commensurate with experience according to the institutional guidelines.

Application

To apply, please send a single PDF file to mael.bessaud@pasteur.fr containing: (1) a cover letter outlining your previous experiences that make you suited for this position as well as your research, training and career goals; (2) your up-to-date CV; (3) contact information for 2/3 references.

References

Razafindratsimandresy et al. Enterovirus detection in different regions of Madagascar reveals a higher abundance of enteroviruses of species C in areas where several outbreaks of vaccine-derived polioviruses occurred. BMC Infect Dis. 2022 Nov 8;22(1):821. doi: 10.1186/s12879-022-07826-0

Joffret et al. Vaccine-Derived Polioviruses, Central African Republic, 2019. Emerg Infect Dis. 2021 ; 27(2):620-623. doi: 10.3201/eid2702.203173

Muslin et al. Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process. Viruses. 2019;11(9):859. doi: 10.3390/v11090859

Bessaud et al. Exchanges of genomic domains between poliovirus and other cocirculating species C enteroviruses reveal a high degree of plasticity. Sci Rep. 2016 Dec 13;6:38831. doi: 10.1038/srep38831