英国利兹大学2024年招聘博士后职位（凝集素聚类与信号传导）

利兹大学（University of Leeds），是一所位于英国利兹的顶尖公立综合研究型大学，英国八大研究引擎之一，世界百强大学，位列2024QS世界大学排名第75位。

Research Fellow in Lectin Clustering and Signalling

University of Leeds

Job Description

Are you an ambitious researcher looking for your next challenge? Do you have a background in protein functional studies? Are you interested in exploiting multidisciplinary approaches to address challenging biological questions? Do you want to further your career in one of the UK's leading research-intensive universities?

We are looking for a highly motivated BBSRC-funded Postdoctoral Research Fellow to join a dynamic, interdisciplinary team, focusing on employing protein engineering, surface biophysical techniques and high resolution imaging to elucidate mechanisms underlying multivalent interactions inducing protein clustering on surfaces and modulating immune cell signalling. You will actively work with supervisors from the Schools of Food Science & Nutrition Chemistry, Physics & Astronomy and Chemical & Process Engineering. The supervision team has strong track records (see example papers, J. Am. Chem. Soc. 2017, 139, 10833; 2020, 142, 18022; 2022, 144, 17346; Nature Chem. 2020, 12, 832; Angew. Chem. 2022, 134, e202206919; JACS Au, 2023, 3, 1755; Adv. Mater. 2021, 33, 2008307) and complimentary expertise and skills in this research field.

You will be responsible for producing recombinant proteins, anchoring them onto supported-lipid bilayers, monitoring how ligand binding induces protein clustering and re-arrangement, and correlating results with cellular function outcomes. The project aimsto deepen our understanding on how extracellular multivalent binding signals are transmitted across cell membranes and regulate immune cell functions, allowing us to manipulate immune responses as potential effective treatments against infectious and autoimmune diseases and other immune dysregulation diseases, including cancer.

To explore the post further or for any queries you may have, please contact:

Dr Yuan Guo

Email: y.guo@leeds.ac.uk

Professor Dejian Zhou

Email: d.zhou@leeds.ac.uk

Location: Leeds - Main Campus

Faculty/Service: Faculty of Environment

School/Institute: School of Food Science & Nutrition

Category: Research

Grade: Grade 7

Salary: £37,099 to £44,263 p.a.

Working Time: 100%

Post Type: Full Time

Contract Type: Fixed Term (for 30 months from 1st May 2024)

Release Date: Thursday 07 March 2024

Closing Date: Thursday 04 April 2024

Reference: ENVFS1101