一、中心简介

首都医学科学创新中心（简称创新中心）是北京市新成立的具有独立法人资格的新型研发机构。创新中心以推动医学科学发展、改善人类健康为目标，开展生物医学研究，致力于提升医学科学创新与成果转化能力，提高疾病诊断和治疗水平。我们将汇聚世界高水平科学家及其科研团队，与首都医学教育和科学研究优质资源紧密合作，打造多学科交叉融合的科研平台，综合自由探索、医学目标导向、有组织科研等途径，实践新型科研模式和体制机制，逐步推进医教研产的深度融合，培养适应医学科学创新发展的优秀人才。

二、实验室介绍

郭鹏飞研究员先后在江南大学、北京大学/北京生命科学研究所获得学士博士学位，约翰霍普金斯大学医学院和德克萨斯大学西南医学中心博士后研究，西湖大学任职副研究员，将于2025年1月加入首都医学科学创新中心（CIMR）创建独立实验室。实验室将致力于研究组织和器官生长发育的调控机制，并在此基础上开发针对肿瘤、先天性发育缺陷等疾病的治疗方法。

三、实验室研究方向

实验室将综合利用各类模式生物系统，结合功能基因组筛选、细胞生物学、蛋白质组学、单细胞测序、代谢组学、生物信息学等手段开展以下课题研究：

1.通过全基因组筛选，鉴定调控组织生长和器官大小的关键基因，揭示器官发育和组织再生背后的遗传网络和信号通路。

2.研究组织力学在调控组织生长中的作用，特别是机械力和组织的机械性质如何影响细胞行为。此外，我们还研究肿瘤微环境的力学特性如何影响肿瘤生长和免疫反应。

3.研究Hippo信号通路在正常发育过程中的作用及其失调如何导致先天性发育疾病，特别是神经发育疾病。

四、代表性文章

Science.2024.385(6709):eadf4478.PMID: 39116228.

eLife.2019.22:8:e38843.PMID: 30901309.

PNAS.2010.107(42):18016–18021.PMID: 20921409.

五、岗位信息

01科研助理

1）主要职责

1.独立或协助团队开展课题研究；

2.管理和维护实验室日常工作和行政事务。

2）任职要求

1.大学本科学历及以上，生物学、基础医学等相关专业；

2.掌握常规分子克隆、细胞培养或动物实验的操作及原理，有实验室研究工作经历优先；

3.具备良好的沟通能力和团队协作能力；

4.具备良好的英语读写和日常交流能力。

02博士后

1）主要职责

1.在课题组长指导下独立开展研究工作；

2.协助指导研究生工作以及撰写论文或基金申请。

2）任职要求

1.具有生命科学或其他相关生物医学领域的研究背景，即将获得博士学位或已获得博士学位（原则上不超过2年）；

2.有小鼠肿瘤模型、发育生物学、全基因组CRISPR筛选或生物信息学背景者优先考虑；

3.以第一作者身份在领域内主流期刊上发表过或即将发表研究论文，能够独立开展研究工作，具有科研热情和严谨的科研态度；

4.具备良好的英语读写和日常交流能力，能够使用英文撰写论文。

六、福利待遇

1.根据应聘者的工作经验和能力，提供具有市场竞争力的薪酬（详情面谈）；

2.享受五险一金、带薪年假、体检和补充医疗保险等；

3.支持个人职业发展，提供必要的工作相关专业培训。

七、申请方法

应聘者请将个人简历、研究兴趣或计划，以及2-3名推荐人（仅限博士后应聘）的姓名及联系方式，以及其他能证明科研能力的相关电子文件发送到邮箱

guopengfei@cimrbj.ac.cn，请【点击下方“立即投递/投递简历”，即刻进行职位报名】，邮件主题请注明“应聘者名字+具体应聘职位”。

联系人：老师

联系地址：北京市丰台区右安门外西头条10号-首都医学科学创新中心

本招聘长期有效，至招聘到合适人选为止。

ABOUT CIMR

The Chinese Institutes for Medical Research (CIMR) is a newly founded institution dedicated to fundamental and translational medical research.The CIMR is located at the main campus of the   ,  and committed to building a scientist-centered governance framework and fostering a diverse and inclusive work environment.For more information, please visit our website: www.cimrbj.ac.cn

Laboratory Introduction

The Guo laboratory at CIMR works on uncovering the molecular and genetic mechanisms that regulate tissue growth and organ size control, as well as understanding how dysregulation of these processes contributes to human diseases.

Major Research Projects

The Guo lab will use various model systems and integrate cutting-edge techniques in genetics, cell biology, and bioinformatic, with the aims of elucidating fundamental biological principles and identifying novel pathways involved in disease pathogenesis.

a.Conducting genome-wide screening in Drosophila and mouse models to identify key genes that regulate tissue growth and organ size.

b.Investigating the role of tissue mechanics in regulating tissue growth and how physical forces and mechanical properties influence cellular behavior.Additionally, we explore how the tumor microenvironment’s physical properties affect tumor growth and immune response.

c.Investigating the role of the Hippo signaling pathway in normal developmental processes and how its disruption contributes to congenital developmental diseases, with a particular focus on neurodevelopmental disorders.

Representative Publications

Science.2024.385(6709):eadf4478.PMID: 39116228.

eLife.2019.22:8:e38843.PMID: 30901309.

PNAS.2010.107(42):18016–18021.PMID: 20921409.

Open Positions

Research Assistant

Main Responsibilities

a.Conducting research projects independently or in collaboration with other lab members.

b.Getting involved in lab data analysis and management.

Qualifications

a.B.S or higher degree in biology, basic medical science and other relevant majors is required.

b.Research experience in molecular biology, biochemistry, cell biology and/or mouse studies is preferred.

c.Self-motivated researcher with good communication skill and teamwork ability.

d.Proficient in English reading, writing, and daily communication.

Postdoctoral Researcher

Main Responsibilities

a.Conducting research projects independently.

b.Assisting PI to mentor graduate students, write grant proposals and manuscripts.

Qualifications

a.Backgrounds in biology or biomedical fields.Either about to obtain a Ph.D.or recently obtained a Ph.D.degree (ideally within the last 2 years).

b.Candidates with experience in mouse tumor models, developmental biology, or genome-wide CRISPR screening are preferred.

c.Proven ability to conduct independent research, demonstrated by a first-author publication in a reputable journal in the field (or a paper accepted for publication).

d.Proficient in English reading, writing, and daily communication.Capable of writing papers in English.

Welfare Treatment

a.Competitive salary based on the job applicant's work experience and abilities (salary negotiable).

b.Social insurance, paid annual leave, physical examination and supplementary medical insurance, etc.

c.Supporting personal career development and providing necessary job related professional training.

How to apply

To apply, please send personal resume, research interest or plan, the names and contacts of 2-3 referees (for postdoc position only) and other materials demonstrating research capabilities to guopengfei@cimrbj.ac.cn, and indicate the applicant's name and specific job position in the email subject.

Contact person: Pengfei Guo

This recruitment is valid for the long term until a suitable candidate is recruited.