一、中心简介

首都医学科学创新中心（简称创新中心）是北京市新成立的具有独立法人资格的新型研发机构。创新中心以推动医学科学发展、改善人类健康为目标，开展生物医学研究，致力于提升医学科学创新与成果转化能力，提高疾病诊断和治疗水平。我们将汇聚世界高水平科学家及其科研团队，与首都医学教育和科学研究优质资源紧密合作，打造多学科交叉融合的科研平台，综合自由探索、医学目标导向、有组织科研等途径，实践新型科研模式和体制机制，逐步推进医教研产的深度融合，培养适应医学科学创新发展的优秀人才。

二、实验室介绍

Hansen实验室专注于研究兴奋性细胞在天然三维状态下的信号传导，以便更好地理解人类疾病的分子基础。通过研究这些分子机制，旨在阐明疾病的发展过程，并开发出预防或减轻疾病影响的治疗方法。

三、主要研究课题

1.利用超分辨率成像和空间生物学建立膜介导麻醉的分子基础。

2.研究胆固醇在驱动炎症性疾病（包括阿尔茨海默症和慢性疼痛）中的分子作用。

3.利用新型药物发现试验开发非成瘾性镇痛药（止痛药）。

4.揭示低阈值时膜介导的机械感觉的分子基础。

四、主要成果与贡献

1.在哺乳动物细胞和果蝇中发现了一种膜介导的麻醉作用机制（PNAS, 2020）。

2.建立了调节钾通道的膜介导机械感觉机制（eLife, 2024; Nature Communications, 2016）。

3.发现星形胶质细胞胆固醇是阿尔茨海默症中淀粉样蛋白生成的调节因子（PNAS, 2021）。

4.证明信号脂质可作为离子通道的直接激动剂（BBA, 2016; Nature, 2011）。

五、代表性文章

eLife, 2024, 12: RP89465.DOI: 10.7554/eLife.89465.

Pharmacology & Therapeutics, 2023, 249: 108486.DOI: 10.1016/j.pharmthera.2023.108486.

The Journal of biological chemistry, 2023, 299: 104763.DOI: 10.1016/j.jbc.2023.104763.

PNAS, 2021, 118: e2102191118.DOI: 10.1073/pnas.2102191118.

PNAS, 2020, 117: 13757–13766.DOI: 10.1073/pnas.2004259117.

六、岗位信息

01博士后

1）主要职责

1.独立开展课题研究项目；

2.协助PI指导研究生，撰写论文及基金申请。

2）任职要求

1.生物学、生物化学或生物医学领域背景。获得博士学位（最近两年内优先）或即将完成博士学位；

2.以第一作者身份在领域内主流期刊上发表过或即将发表研究论文；

3.有电生理学、超分辨率显微镜或冷冻电镜研究经验者优先；

4.在分子生物学、蛋白质纯化、原代细胞培养和/或小鼠研究方面有丰富的研究经验；

5.精通英语阅读、写作和日常沟通，能够使用英语撰写论文。

02实验室管理员

1）主要职责

1.订购和管理实验室耗材和试剂，制备常用缓冲液和溶液；

2.实验室日常管理及费用核算和报销；

3.安排实验室会议和其他例行活动。

2）任职要求

1.本科及以上学历，生命科学、医学等相关专业，有实验室管理工作经验者优先考虑；

2.具有优秀的沟通能力和团队合作能力；

3.精通中英文阅读、写作和日常沟通；

4.熟悉日常办公软件。

七、福利待遇

1.根据应聘者的工作经验和能力，提供具有市场竞争力的薪酬（详情面谈）；

2.享受五险一金、带薪年假、体检和补充医疗保险等；

3.支持个人职业发展，提供必要的工作相关专业培训。

八、申请方法

请将简历、研究兴趣或计划（仅限博士后）、2-3名推荐人的姓名和联系方式以及其他证明研究能力的材料发送至shansen@cimrbj.ac.cn，并在邮件主题中注明申请人的姓名和具体职位。

联系人：Scott Hansen

联系地址：北京市丰台区右安门外西头条10号-首都医学科学创新中心

本招聘长期有效，至招聘到合适人选为止。

ABOUT CIMR

The Chinese Institutes for Medical Research (CIMR) is a newly founded institution dedicated to fundamental and translational medical research.The CIMR is located at the main campus of the   ,  and committed to building a scientist-centered governance framework and fostering a diverse and inclusive work environment.For more information, please visit our website: www.cimrbj.ac.cn

Laboratory Introduction

The Hansen Laboratory at CIMR focuses on studying the signaling of excitable cells in their native three-dimensional state to better understand the molecular basis of human disease.By investigating these molecular mechanisms, we aim to elucidate disease progression and develop therapies to prevent or mitigate its impact.

Major Research Projects

1.Establishing the molecular basis for membrane-mediated anesthesia using super-resolution imaging and spatial biology.

2.Investigating the molecular role of cholesterol in driving inflammatory diseases, including Alzheimer’s disease and chronic pain.

3.Developing non-addictive analgesics (pain medications) using novel drug discovery assays.

4.Uncovering the molecular basis of membrane-mediated mechanosensation at low thresholds.

Major Contributions

1.Identified a membrane-mediated mechanism of anesthetic action in mammalian cells and in fruit fly (PNAS, 2020)

2.Established a membrane-mediated mechanism of mechanosensation regulating a potassium channel (eLife, 2024; Nature Communications, 2016)

3.Identified astrocyte cholesterol as a regulator of amyloid production in Alzheimer’s Disease (PNAS, 2021)

4.Demonstrated that signaling lipids act as direct agonists of ion channels (BBA, 2016; Nature, 2011)

Representative Publications

eLife, 2024, 12: RP89465.DOI: 10.7554/eLife.89465.

Pharmacology & Therapeutics, 2023, 249: 108486.DOI: 10.1016/j.pharmthera.2023.108486.

The Journal of biological chemistry, 2023, 299: 104763.DOI: 10.1016/j.jbc.2023.104763.

PNAS, 2021, 118: e2102191118.DOI: 10.1073/pnas.2102191118.

PNAS, 2020, 117: 13757–13766.DOI: 10.1073/pnas.2004259117.

Open Positions

Postdoctoral Researcher

Main Responsibilities

a.Conduct research projects independently.

b.Assist PI to mentor graduate students, write grant proposals and manuscripts.

Qualifications

a.Backgrounds in biology, biochemistry, or biomedical fields.A recent Ph.D.degree (ideally within the last 2 years) or about to complete a PhD.

b.Published or about to publish a first author research paper in a reputable journal.

c.Research experience in electrophysiology, super-resolution microscopy, or cryoEM is appreciated and favored.

d.Strong research experience in molecular biology, protein purification, primary cell culture, and/or mouse studies.

e.Proficient in English reading, writing, and daily communication.Capable of writing papers in English.

Laboratory Manager

Main Responsibilities

a.Order and manage laboratory consumables and reagents and prepare commonly used buffers and solutions.

b.Laboratory daily management and expense accounting and reimbursement.

c.Arrange lab meetings and other routine activities.

Qualifications

a.Have a bachelor's degree or above degree in life science- or medicine-related majors.

b.Have excellent communication skills and teamwork skills.

c.Proficient in English and Chinese reading, writing, and daily communication.

d.Familiar with daily office software.

e.Priority will be given to applicants with laboratory management experience.

Welfare Treatment

a.Provide competitive salary based on the applicant’s work experience and ability (salary negotiable).

b.Provide social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.

c.Support career development and provide relevant professional guidance.

How to apply

Please send a resume, research interest or plan (for postdoc position only), the names and contacts of 2-3 referees and other materials demonstrating research capabilities to shansen@cimrbj.ac.cn, and indicate the applicant's name and specific job position in the email subject.

Contact person: Scott Hansen

This recruitment is valid for the long term until a suitable candidate is recruited.

信息来源于网络，如有变更请以原发布者为准。

来源链接：

https://mp.weixin.qq.com/s/eOTc_VJ6TLmaj_LX2zkklg