一、中心简介

首都医学科学创新中心（简称创新中心）是北京市新成立的具有独立法人资格的新型研发机构。创新中心以推动医学科学发展、改善人类健康为目标，开展生物医学研究，致力于提升医学科学创新与成果转化能力，提高疾病诊断和治疗水平。我们将汇聚世界高水平科学家，与首都医学教育和科学研究优质资源紧密合作，打造多学科交叉融合的科研平台，综合自由探索、医学目标导向、有组织科研等途径，实践新型科研模式和体制机制，逐步推进医教研产的深度融合，培养适应医学科学创新发展的优秀人才。

二、实验室介绍

冷方伟研究员本科毕业于四川大学吴玉章学院，在中科院生物物理研究所获得博士学位后加入哈佛医学院/HHMI Sun Hur实验室担任博士后/讲师，将于2025年5月加入首都医学科学创新中心创建独立实验室，围绕蛋白质互作、染色质三维结构及表观遗传修饰等方面系统研究调节性T细胞（Treg）的工作机制，并设计靶向关键蛋白如FoxP3的小分子，多肽药物和纳米抗体以调控调节性T细胞功能，开发自身免疫疾病和肿瘤治疗策略。

实验室网站：https://www.cimrbj.ac.cn/channel/1896742745033281536.html

三、主要研究方向

1.调节性T细胞在免疫稳态与疾病发生中的机制研究；

2.靶向调节性T细胞功能的药物开发；

3.探索微卫星DNA的生物学功能及其潜在的临床相关性。

01主要成果与贡献

1.揭示了FoxP3两种二聚化状态对调节性T细胞功能的影响（Immunity，2022，封面文章）；

2.发现FoxP3识别并桥接TnG微卫星DNA以促进增强子-启动子环化（Nature，2023）；

3.发现FoxP3通过不同多聚体结构识别多种微卫星DNA以重塑染色质三维结构 （Molecular Cell，2025）。

02代表性文章

Molecular Cell.2025 (In press)

Nature.2023 Dec; 624(7991): 433-441.PMID: 38030726

Immunity.2022 Aug 9; 55(8): 1354-1369.e8.PMID: 35926508

四、岗位信息

01博士后

1）岗位职责

1.独立开展课题研究项目；

2.协助PI指导研究生, 撰写论文及基金申请。

2）任职要求

1.具有免疫学、生物信息学、分子生物学、细胞生物学、生物化学或其他生物医学领域研究背景，即将或已经获得博士学位（原则上不超过3年）；

2.以第一作者身份在领域内主流期刊上发表过或即将发表研究论文，能够独立开展研究工作，具有科研热情和严谨的科研态度；

3.有免疫学、基因组学、生物信息学等研究经验者优先；

4.精通英语阅读、写作和日常沟通，能够使用英语撰写论文。

02科研助理

1）岗位职责

1.独立或协助团队开展研究工作；

2.管理和维护实验室日常工作和行政事务。

2）任职要求

1.具有化学、药学、生物学、基础医学等相关专业的本科及以上学位；

2.掌握常规分子克隆、生物化学、细胞培养的操作及原理，有实验室研究工作经历优先；

3.有较强的主观能动性，具备良好的沟通能力和团队协作能力；

4.具备良好的英语读写和日常交流能力，能够使用英文撰写论文。

五、福利待遇

1.根据应聘者的工作经验和能力，提供具有市场竞争力的薪酬（详情面谈）；

2.享受五险一金、带薪年假、体检和补充医疗保险等；

3.支持个人职业发展，提供必要的工作相关专业培训。

六、申请方法

请将简历、个人陈述（1页）、2名推荐人的基本信息和联系方式、工作总结与研究兴趣（1-2页，仅限博士后）以及其他申请人认为必要的材料，合并为PDF文件发送至fangwei.leng@cimrbj.ac.cn， 并在邮件主题中注明：“应聘博士后/科研助理+本人姓名+所在学校/单位”，初审通过的申请者将会尽快安排面试。

联系人：冷老师

联系地址：北京市丰台区右安门外西头条10号-首都医学科学创新中心

本招聘长期有效，至招聘到合适人选为止。

ABOUT CIMR

Chinese Institutes for Medical Research (CIMR) is a newly founded institution dedicated to fundamental and translational medical research.The CIMR is located at the main campus of the Capital Medical University, Beijing, China and committed to building a scientist-centered governance framework and fostering a diverse and inclusive work environment.For more information, please visit our website: www.cimrbj.ac.cn

Laboratory Introduction

The Leng Laboratory at CIMR investigates the molecular mechanisms by which FoxP3 regulates the gene network of regulatory T cells (Tregs).Our research explores multiple perspectives, including the protein interactome, three-dimensional chromatin architecture, and epigenetic modifications.Our long-term goal is to develop drugs targeting FoxP3 to modulate Treg activity, providing potential therapeutic strategies for both autoimmune diseases and cancer.

Major Research Projects

a.Exploring the molecular mechanisms of FoxP3 in regulating the gene expression in Tregs.

b.Developing small molecules, Peptides and Nanobodies to Modulate FoxP3 Function.

c.Exploring the role of microsatellites in gene regulation and genetic disorders.

Major Contributions

a.Uncovering the critical role of FoxP3 head-to-head dimerization in Treg function (Immunity, 2022).

b.Discovering that FoxP3 recognizes and multimerizes on TnG repeat microsatellites, revealing a novel DNA-bridging mechanism (Nature, 2023).

c.Revealing the role of versatile FoxP3 ensembles in three-dimensional genomic architecture (Molecular Cell, 2025).

Representative Publications

Molecular Cell.2025 (In press)

Nature.2023 Dec; 624(7991): 433-441.PMID: 38030726

Immunity.2022 Aug 9; 55(8): 1354-1369.e8.PMID: 35926508

Open Positions

Postdoctoral Researcher

Main Responsibilities

a.Conducting research projects independently.

b.Assisting PI to mentor graduate students, write grant proposals and manuscripts.

Qualifications

a.Backgrounds in biology or biomedical fields.Either about to obtain a Ph.D.or recently obtained a Ph.D.degree (ideally within the last 3 years).

b.Published or about to publish research papers as the first author in reputable journals in the field.With motivation and ability to independently carry out research projects.

c.Research experience in immunology, Genomics and Bioinformatics is appreciated and favored.

d.Proficient in English reading, writing, and daily communication.Capable of writing papers in English.

Research Assistant

Main Responsibilities

a.Conducting research projects independently or in collaboration with other lab members.

b.Getting involved in lab data analysis and management.

Qualifications

a.A B.S or higher degree in biology, basic medical science and other relevant majors is required.

b.Research experience in molecular biology, biochemistry, cell biology is preferred.

c.Self-motivated researcher with good communication skill and teamwork ability.

d.Proficient in English reading, writing, and daily communication.

Welfare Treatment

a.Provide competitive salary based on the applicant’s work experience and ability (salary negotiable).

b.Provide social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.

c.Support career development, provide relevant professional guidance.

How to apply

Please compile your CV, one-page personal statement, basic information and contact details of two referees and a 1-2 page research summary and interests (for postdoc position only), as well as other materials demonstrating research capabilities into a single PDF file.Send it to fangwei.leng@cimrbj.ac.cn, and indicate “Postdoc/Research Assistant + Your Name + University/Employer” in the email subject.Review of applications will begin on a rolling basis, and qualified applicants will be invited for an interview.

Contact person: Dr.Leng

This recruitment is valid for the long term until a suitable candidate is recruited.

信息来源于网络，如有变更请以原发布者为准。

来源链接：

https://mp.weixin.qq.com/s/FESfAjYveXhYElETO3Frbg