英国医学研究委员会（MRC）2024年招聘博士后（NATA（核酸治疗加速器））

英国医学研究委员会，创建于1920年，系隶属于教育与科学国务大臣的政府机构。该委员会下设应用心理学研究所、环境心理学研究所、尘肺研究所和毒理学研究所等机构。全委员会共有成员4274人，其中研究人员2771人。

Postdoctoral Researcher – Biology

Employer

NATA

Location

Harwell, Didcot

Salary

£39,375-£41,843 per annum

Closing date

28 Jan 2024

Discipline

Biomedicine, Life Science

Job Type

Postdoctoral, Researcher

Employment - Hours

Full time

Duration

Permanent

Qualification

PhD

Sector

Charity/NGO

Postdoctoral Researcher – Biology

Harwell, Didcot

£39,375-£41,843 per annum (Depending on experience)

Permanent

Full time on-site – 36 hours per week

About us

The Medical Research Council (MRC), as part of UK Research and Innovation (UKRI), has invested £30m over 4 years through the Strategic Priorities Fund to establish a Nucleic Acid Therapy Accelerator (NATA) that will support state-of-the-art interdisciplinary research to solve critical issues in nucleic acid drug development, through focused NATA research challenges and a NATA infrastructure hub.

NATA (https://www.natahub.org/) focuses on building internal chemistry, biology and operational capabilities while catalysing collaborative R&D activity to tackle significant barriers facing oligonucleotide therapy manufacturing and delivery. This investment will support capacity building in terms of equipment, upskilling and domain expertise that will be essential in developing critical mass to catalyse and de-risk the development of next-generation nucleic acid therapeutics.

About the Role

We are seeking to appoint a highly motivated and enthusiastic postgraduate scientist. The Biology Researcher will be critical in supporting the NATA biology department by developing new techniques and methods related to the assessment of delivery, toxicity and efficacy of nucleic acid therapeutics in multidisciplinary projects. This individual will be involved in the development of new techniques and methods for 1) the quantification and localization of nucleic acid therapeutics after administration in vitro and in vivo, 2) the mechanism of uptake of new nucleic acid therapeutic conjugates, 3) the assessment of clearance and pharmacokinetic parameters associated to nucleic acid therapeutics. They will report to the Head of Biology.

About You

You will have:

Hold a relevant Ph.D/D.Phil in biology, biochemistry pharmacology, toxicology or a related discipline

Peer-reviewed research publications commensurate with career stage

Experience of conventional and advanced cell culture approaches with cell lines / primary cells

Fluorescence/confocal microscopy and image analysis

Cell-based screening assays such as ELISA, luciferase, qPCR and western blotting

Key Responsibilities include:

Undertake laboratory experiments as required by the project and analyse/report data (presentations, verbal and written report)

Carry out target design, target screening, validation and toxicology assessment of nucleic acid therapeutics

Perform efficacy assessment using mRNA/protein quantification methods and functional assessments including immunofluorescence and confocal imaging

Research and establish new techniques and methods for quantification and localization of nucleic acid therapeutics after administration in vitro and in vivo

For the full job description, please visit our site.

Benefits:

Choosing to come to work at the MRC (part of UK Research and Innovation (UKRI)) means that you will have access to a whole host of benefits, from a defined-benefit pension scheme and excellent holiday entitlement, to access to employee shopping/travel discounts and a salary sacrifice cycle to work scheme. In addition, you will have the opportunity to contribute to the work of a world-class medical research organisation.

How to Apply:

For full details and to apply, please click apply to submit an application. Your cover letter should clearly outline how you fulfil the criteria listed in the personal specification and your motivation for applying for this role.

Please quote reference NATA 2321

The closing date for applications is Sunday 28th January 2024